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KMID : 1130620220180040391
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Journal of Clinical Neurology
2022 Volume.18 No. 4 p.391 ~ p.400
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Potential of Transcranial Direct Current Stimulation in Alzheimer’s Disease: Optimizing Trials Toward Clinical Use
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Pilloni Giuseppina
Charvet Leigh E.
Bikson Marom
Palekar Nikhil
Kim Min-Jeong
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Abstract
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Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive method for stimulating the brain that is rapidly developing into a treatment method for various neurological and psychiatric conditions. In particular, there is growing evidence of a therapeutic role for tDCS in ameliorating or delaying the cognitive decline in Alzheimer’s disease (AD). We provide a brief overview of the current development and application status of tDCS as a nonpharmacological therapeutic method for AD and mild cognitive impairment (MCI), summarize the levels of evidence, and identify the improvements needed for clinical applications. We also suggest future directions for large-scale controlled clinical trials of tDCS in AD and MCI, and emphasize the necessity of identifying the mechanistic targets to facilitate clinical applications.
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KEYWORD
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transcranial direct current stimulation, Alzheimer disease, clinical trial
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